FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLET USING NATURAL TREE GUMS

Formulation And In Vitro Evaluation of Colon Targeted Matrix Tablets of Mebeverine Hydrochloride Using Natural Polymers

BACKGROUND: The present study focuses on the design and evaluation of colon targeted matrix tablets of Mebeverine hydrochloride using natural gums like guar gum, xanthan gum at different concentrations. This novel approach is expected to be promising drug delivery system for delivering Mebeverine HCl to the colon for its local action and thereby minimizing systemic side effects of the drug. MET...

Formulation and In Vitro Evaluation of Extended Release Tablets of Paliperidone Using Natural Gums

Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In the present study Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. The optimized formulations contain Paliperidone as...

Formulation and Evaluation of Sustained Release Metoprolol Succinate Tablet using Hydrophilic gums as Release modifiers

The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using natural hydrophilic gums such as karaya gum and xanthan gum as a release modifier. Nine batches were prepared by using karaya gum (KG) and xanthan gum (XG) in concentration of 15%, 20% and 25% alone and in combination of 2:8. Matrix tablets were prepared by wet granulation m...

Formulation and In vitro evaluation of colon targeted mesalazine tablet for the treatment of chronic pancreatitis

Formulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery

   The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...